Table 3 Status and findings of clinical trials on stem cell therapy in dementia
From: Stem cell therapy use in patients with dementia: a systematic review
NCT | Status | Phase | Cell Type | Route | Findings |
|---|---|---|---|---|---|
NCT01297218 [30] | Completed | 1 | Human UCB-MSCs | IC Infusion | Acute adverse events in all 9 subjects during a 12-week follow-up |
No serious adverse events in a 24-month follow-up | |||||
No dose-limiting toxicity | |||||
NCT03724136 [32] | Recruiting | - | BMSC | IV Fraction | Not yet published |
NCT04388982 [33] | Unknown | 1/2 | MSCs-Exos | Nasal drip | Not yet published |
NCT04040348 [41] | Completed | 1 | Allogeneic human UCB-MSCs | IC Infusion | Not yet published |
NCT01696591 [42] | Unknown (follow-up study) | - | - | - | Not yet published |
NCT02795052 [43] | Recruiting | - | BMSCs | IV and intranasal infusion | Not yet published |
NCT04228666 [34] | Withdrawn (Due to COVID-19 Pandemic) | 1/2 | HB-adMSCs | IV infusion | N/A |
NCT04855955 [44] | No Longer Available | - | Autologous human AD-MSCs | - | Not yet published |
NCT02672306 [45] | Unknown | 1/2 | Human UCB-MSCs | IV infusion | Not yet published |
NCT01547689 [46] | Unknown | 1/2 | Human UCB-MSCs | IV infusion | Not yet published |
NCT02054208 [31] | Completed | 1/2a | Human UCB-MSCs | IVT infusion | Acute adverse events within 36 h |
Serious adverse events in 3 subjects | |||||
No dose-limiting toxicity | |||||
NCT02600130 [47] | Completed | 1 | LMSCs | IV infusion | Not yet published |
NCT04954534 [48] | Unknown (follow-up study) | - | - | - | Not yet published |
NCT03117738 [35] | Completed | 1/2 | Autologous Ad-MSCs | IV infusion | Serious adverse events in 3 out of 11 subjects |
Other adverse events in 3 out of 11 subjects | |||||
NCT03172117 [49] | Completed (follow-up study) | - | - | - | All patients had adverse events |
NCT02912169 [50] | Withdrawn (company dissolved) | 1/2 | Autologous AD-SVF | IV and intranasal infusion | Not yet published |
NCT04482413 [51] | Not yet recruiting | 1/2b | Autologous ADSCs | IV infusion | Not yet published |
NCT03297177 [52] | Unknown | 1/2 | Autologous microvasculature stem/stromal cells | IV infusion | N/A |
NCT03899298 [53] | Not yet recruiting | 1 | Human UCB-MSCs | IV, intranasal, nebulizer dependent on patient condition | Not yet published |
NCT04684602 [54] | Recruiting | 1/2 | Human UCB-MSCs | IV, intranasal, nebulizer dependent on patient condition | Not yet published |
NCT02899091 [55] | Active, not recruiting | 1/2 | Human UCB-MSCs | IV infusion | Not yet published |